Posters

FARNESOL SUPPRESSES LIPID ACCUMULATION IN HepaRG CELL BASED MODEL OF HEPATIC STEATOSIS.
Asmita Pant¹, and Thomas A. Kocarek^1
1 Institute of Environmental Health Sciences, Wayne State University, Detroit, MI 48201

Evaluation of a single-well cytochrome CYP3A4/5, 1A2 and 2B6 induction assy using hepatocytes dervied from HepaRG™ cell line. - ISSX 2014
Rachel Mandell Basile¹, Gary Park¹, David Sweeny¹, Maurice Standlee¹, Susan Grepper², David Lau^1
1 Department of Drug Metabolism and Pharmacokinetics, Rigel Pharmaceuticals, South San Francisco, CA
² CellzDirect/Life Technologies, Durham, NC 

Evaluation of differentiated cryopreserved HepaRG cells as a model for hepatic clearance and UGT activity. - Rennes Workshop 2011
Malin Darnell^1,2 and Tommy B Andersson^1,2
1 AstraZeneca R&D, Sweden
² Karolinska Institute, Stockholm, Sweden

 
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Measuring CYP3A induction in combination with cell viability in multiplex cell-based assays formats. - ISSX 2010
James J. Cali¹, Marie Sobol¹, James Unch¹, Thimothy Moeller², Brad Larson³ and David Steen⁴
1 Promega Corp
2 Celsis/IVT inc
3 Biotek Instruments
4 Biopredic International

 
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Prediction of clearance from the HepaRG cell system: comparison with human hepatocytes for a range of substrates. - ISSX 2010
Ugo Zanelli¹, Nicola Pasquale Caradonna¹, David Hallifax² and James Brian Houston^2
1 Met profiling unit, Screening & Technology department, Siena Biotech, Strada del Petriccio e Belriguardo, 35, 53100 Siena, Italy
² School of Pharmacy and Pharmaceuticals Sciences, The university of Manchester, Manchester, UK

Nuclear Receptor Signaling in HepaRG Cells. - ISSX 2009
Dan Brobst¹ and Jeff L. Staudinger^1
1 Department of Pharmacology and Toxicology, University of Kansas, Lawrence, KS 66045 

Human HepaRG™ cells, a useful in vitro model for cell-based cholestasis assays - ISSX Orlando 2015
F.Brée¹, S.camus³, D.Steen¹³, C.Guguen-Guillouzo^2-3
1 Eurosafe, Parc d’affaires de la Breteche, Bat B1, F-35760- Saint Grégoire – francoise.bree@eurosafe.fr
² Inserm UMT991, F-35000-Rennes
³ Biopredic International, Parc d’affaires de la Breteche, Bat A4, F-35760- Saint Grégoire

A High-Content Analysis Assay to Predict Human Hepatotoxicity in HepaRG and HepG2 cells - SOT 2015
Junichiro Saito¹, Ai Okamura¹, Kenichiro Takeuchi¹, Kenichi Hanioka¹, Akinobu Okada¹, and Takeji Ohata^2
1 Drug Safety Research Labs. Astellas Pharma Inc, Osaka, Japan.
² Research Program Management Office, Astellas Pharma Inc, Miyukigaoka, Japan.

Identification of drug-induced mitochondrial alterations using the HepaRG™ cell line. - ISSX 2014
Nelly Buron¹, Matthieu Porceddu¹, Claire Pertuiset¹, David Steen², Sandrine Camus², Christophe Chesné² and Anne Borgne-Sanchez^1
1 Mitologics S.AS, Paris, France
² Biopredic International, Saint Grégoire, France 

Analysis of Four Hepatotoxicants Using the xCELLigence Analytical System and HepaRG Cells. - SOT 2014
Can Jin¹, David Steen², Valery Schevchenko², Christophe Chesne²  and Yama Abassi^1
1 ACEA Biosciences, San Diego, CA
² Biopredic International, Saint-Grégoire France 

New insights in dose-dependent mechanisms involved in cyclosporine A-induced cholestasis in HepaRG™ cells. Comparison with tacrolimus. - SOT 2014
Ahmad Sharanek ^1,2, Pamela Bachour-El Azzi ^1,2, Houssein Al-Attrache ^1,2, Camille C. Savary^1,2, Christiane Guguen-Guillouzo^1,2,3 and André Guillouzo ^1,2
1 Inserm UMR991, Liver and Metabolisms Cancer, Rennes, France
² University of Rennes 1, Rennes, France
³ Biopredic International, St Grégoire, France 
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Characterization of Cryopreserved HepaRG™ Cells for Multiparameter High Content Analysis. - SOT 2012
Aarati Ranade¹, Simone Graeber¹, Philip Hewitt¹, Stefan O. Mueller¹, Jeff Till¹, Andrew J. Ball^1
1 Merck Millipore

Acetaminophen-induced injury in HepaRG™ cells: a novel human cell line for studies of drug hepatotoxicity. - SOT 2010
Mitchell R. McGill¹, Huimin Yan¹, Anup Ramachandran¹ and Hartmut Jaeschke^1
1 Department of Pharmacology, Toxicology, & Therapeutics, University of Kansas Medical Center, Kansas City, KS

In vitro models for the assessment of drug-induced mitochondrial dysfunction. - Elrig 2013
Conn Carey¹, Ian Hayes¹ and James Hynes^1
1 Luxcel Biosciences, BioInnovation Centre, UCC, Cork, Ireland.

Gene expression profiles in HepaRG™ cells to discriminate genotoxic from non genotoxic compounds. - EEMS 2012
D. Giret¹, A. Huguet¹, S.Camus², N. Rougier², C.Chesné², V. Fessard¹ and L. Le Hegarat^1
1 French Agency for Food, Environmental and Occupational Health & Safety, Toxicology of contaminants Unit, Fougères, France
² Biopredic International, Saint-Grégoire, France

Amiodarone-Induced Phospholipidosis And Steatosis In Human Hepatoma HepaRG Cells. - Liintop Project 2009
Sébastien Anthérieu¹, Christophe Chesné², André Guillouzo^1
1 INSERM U620-MDC, Université de Rennes1, Rennes, France
² Biopredic International, Rennes, France
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Evaluation of the impact of matrix stiffness on encapsulated HepaRG spheroids. - ESACT 2013
Sofia P Rebelo^1,2, Marta Estrada^1,2, Rita Costa^1,2, Christophe Chesné³, Catarina Brito^1,2 and Paula M Alves^1,2
1 iBET, Instituto de Biologia Experimental e Tecnológica, 2780-901 Oeiras, Portugal.
² Instituto de tecnologia Quimica e Biologica, Universida de Nova de Lisboa, 2780-157 Oeiras, Portugal
³ Biopredic International, Saint-Grégoire, France

 

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The human hepatic cell line HepaRG as a possible cell source for the steady generation of humanized liver TK-NOG mice. - CIEA 2013
Hiroshi Suemizu¹,Yuichiro Yiguchi¹, Kenji Kawai¹, Hiroshi Yamazaki², Françoise Bree³, Christiane Guguen-Guillouzo⁴ and Masato Nakamura^5
1 Central Institute of experimental animals.
² Showa Pharmaceutical University
³ Xenoblis
⁴ Biopredic International
⁵ Tokai university school of medicine 

 

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Alterations of the Bile Acid transport system by Cyclosporine A in HepaRG cells. - EUSAAT 2013
Ahmad Sharanek^1,2, Pamela Bachour-El Azzi^1,2,3, Christiane Guguen-Guillouzo^1,2,4, and Andre Guillouzo^1,2
1 Inserm UMR991, Liver Metabolisms and Cancer, Rennes, France
² University of Rennes 1, Rennes, France
³ Lebanese university, Lebanon
⁴ Biopredic International, St Grégoire, France. 
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